UB Expertise

RESEARCH

Discovery of Active Ingredients

• Development of active ingredients of vegetable origin for the cosmetics industry
• Natural antioxidants
• Discovery of cosmetic actives extracted from Peruvian plants
• Design of peptides with various biological properties and cosmetic applications
• Development of recombinant proteins for cosmetic and pharmaceutical applications
• Cosmetic composition for the treatment of spider veins
• Natural antifungal, antioxidant and immunomodulatory products
• Optimization of crops for the development of active ingredients for cosmetics
• Antibiotic activity of macro-algae and their use as preservatives in cosmetic products
• Synthesis of new bioactive molecules, impurities and metabolites
• Gene therapies and tissue engineering
• Functional screening of pharmaceutical and cosmetic active ingredients
• Development of new computational tools for the design of cosmetic agents of interest
• Advice on the use of microorganisms as probiotics and their other potential cosmetic applications

Studies of Efficacy and Toxicity

• Studies of transdermal in vitro permeation of drugs through human skin and swine mucosa for skin and systemic treatment
• Analysis of the effects of drugs and cosmetics after dermal application
• In vitro efficacy and safety models
• Assessment of the irritation and/or allergic potential of dermatological excipients
• Assessment of the in vitro cosmetic efficacy of any given cosmetic composition of previously selected active ingredients
• Assessment of ocular and dermal toxicity of various emulsions
• Evaluation of the cell activity induced by a cosmetic product
• Cell proliferation studies
• Research and development studies of pharmaceutical forms for topical application and self emulsifying drug delivery systems.

DEVELOPMENT

Technical Advice

• Study and fine-tunning of analytical methods for HPLC for raw materials and final products
• Training and advice on experimental techniques as alternatives to animal testing
• Study of the application of new processes in the pharmaceutical industry and other related sectors
• Validation studies of processes, facilities, systems and techniques
• Advice on the development and application of cell models for the improvement of the safety and efficacy of pharmaceutical and cosmetic products
• Development and validation of new in vitro models for their application in the pharmaceutical and cosmetics industries

Galenical Development and Formulation

• Formulation and production of specific formulae.
• Elements for the formulation of foaming agents and emulsions
• General features and elements for the formulation of cosmetic sticks and paste
• Research and development of pellets and micro-capsulation (micro-capsules and nano-capsules).
• Research and development of modified-release pharmaceutical forms: osmotic, colonic, matrix and bioadhesive tablets, bioadhesive gels, etc.
• Pharmaceutical technical study of the compatibility, stability and bio-availability of dermatological active ingredients in topically applied pharmaceutical forms
• Comparative studies of the dissolution and release rate of active ingredients. Influence of formulation on percutaneous absorption
• Optimization studies of formulation and techniques of drug production (human and animal use), healthcare products and other related products
• Low-temperature particle coating
• Galenical development of a line of cosmetic products for personal hygiene

SAFETY, TOXICOLOGY AND REGULATORY ASPECTS 

• Toxicological reports related to the risk of use of cosmetic products
• Analysis of the toxicity of cosmetic compounds
• Detection of endotoxines in pharmaceutical formulae
• Preliminary toxicological screening of bioactive molecules adapted to industrial requirements
• Public health risk assessment; toxicological risk and lethality
• Assessment of health risks related to the reuse of wastewaters
• Preparation of the documentation for the registration of new drugs for both human (CTD) and veterinary (NTA) use
• Design, analytical, numerical and statistical performance and interpretation of results:

o  Preclinical area: formulation stability studies, dissolution rate studies, protein binding studies

o  Clinical area: bioavailability and bioequivalence studies, clinical and population pharmacokinetic studies, pharmacokinetic monitoring studies

o  Postmarketing area: drug information studies, drug use studies, studies of pharmaceutical care in community, hospital and primary healthcare pharmacies

SOCIO-ECONOMIC STUDIES AND TRADEMARK DESIGN

• Market surveys. Analysis of the economic viability of projects. Marketing planning and commercialization
• Marketing, new technologies and social networks
• International trade. Regional, national and international economic organization. International law and relations. International development policies. Economic analysis of public policies
• Packaging and corporate brand design