Area
Nervous SystemIndication
Autism Spectrum DisorderSystem
In vivoZebrafish rbfox1 sa15940 KO model from the Zebrafish Mutation Project, Sanger Institute
Applications
- Behavioural experiments.
- Whole brain imaging using GCaMP6 marker.
- In situ hybridization to study gene expression during development and adulthood.
Principal investigators
Bru Cormand Rifà, Noèlia Fernàndez-CastilloModel relevance
This model allows us to study the effect of loss of RBFOX1 function on neural development and behaviour using different molecular and behavioural approaches and, therefore, characterize RBFOX1 missfunctioning contribution to Autism Spectrum Disorder and aggressive behaviour.
