Experimental models

Area

Nervous System

Indication

Trigeminal Neuralgia and Peripheral Neuropathy

System

In vitro

Model references

Pain 2018 Jan 159(1): 92-105;
Sci Rep. 2016; 6 35775;
Mol Pain 2011; 7: 30;
J. Neurosci 20 April 2011, 31 (16) 6059- 6066;
Sci Signal. 2019 Jun 18;12(586)

Primary cell culture of sensory neurons, cortical and hippocampal neurons

Applications

  • Transient and stable expression of ion channels genes.
  • Intracellular calcium effects and other ion fluxes (by imaging and electrophysiological techniques).
  • Signaling pathways. Drugs testing.
  • Molecular biology: Protein and gene expression techniques (western blot, immunoprecipitation, bio- tinylation, protein expression in yeast).

Principal investigators

Xavier Gasull, David Soto.

Other group publications

X. Gasull at PubMed.
D. Soto at PubMed.

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