Area
OncologyIndication
Malignant CachexiaSystem
In vivoModel references
Int J Cancer. 2016 Apr 15; 138(8):2021-9;
Oncotar- get. 2015 Dec 22; 6 (41):43202-15
Lewis lung carcinoma: model of cancer cachexia in mice of the strain C57BL6
Applications
- Normal vs pathologic studies.
- Therapies effectiveness of cancer cachexia.
- Discovery and validation of targets and pathways involved in the pathology and syndrome evolution.
- Molecular disease markers validation.
- Molecular biology techniques: WB, RT-PCR, optical and electron microscopy, IB, TUNEL.
- Tumor weight measurement.
- Strength measurement (Grip strength test).
- Locomotor activity measurement (IR actimeter Sys- tem with ACTITRAK software).
- Tapes to train animals. Blood tests.
