Experimental models




Liver diseases (injury, fibrosis, cirrhosis and cancer)


In vitro

Model references

Carvajal S et al. Int J Mol Sci. 2019; Ribera J et al Am J Physiol Gastrointest Liver Physiol. 2017

Human umbilical vein endothelial cells (HUVEC)


  • Molecular biology assays in response to treatments with drugs, gene therapy or functional nanoparticles.
  • Cell re-programming (knock-in and knock-out).
  • Cell migration assays.
  • Cell proliferation and viability assays.
  • Cell adhesion assays.
  • Cell culture in hypoxic conditions.
  • Oxidative stress analysis.
  • Induction of Fatty acid accumulation and measurements by gas chromatography and mass spectrometry.

Principal investigators

Wladimiro Jiménez, Pedro Melgar-Lesmes.

Model relevance

Well-established cell lines representative for every hepatic cell subpopulation for the study of signaling pathways affected by different treatments and to assess toxicity and effectivity of novel biomaterials or nanotherapeutics.

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