Area
GastrointestinalIndication
Liver diseases (injury, fibrosis, cirrhosis and cancer)System
Ex vivoHuman, rat and mouse – Precision cut liver slices (PCLS)
Applications
- Investigation of the effects of novel drugs, adenovirus or nanoparticle therapies in a milieu that retains the architecture, interactions, and multicellular characteristics of the healthy and cirrhotic hepatic tissue using PCLS. Comparison between species.
Hepatotoxicity studies. - Cell distribution and ultrastructural analysis of treatment with nanoparticles.
- Evaluation of the dose-effect response of a new treatment in human hepatic cells.
Principal investigators
Wladimiro Jiménez, Pedro Melgar-Lesmes.Model relevance
Well established pre-clinical tool to evaluate toxicity, therapeutic efficacy and dose-response of new drugs or functionalized nanoparticles in humans, and also in rats or mice.
