Area
Endocrine, Nutritional and Metabolic DiseasesIndication
Type 2 Diabetes MellitusSystem
In vivoModel references
Diabetes. 2016 Oct; 65 (10):3185-99;
Metabolism. 2018 Aug; 85:59-75
High fat diet induced type 2 diabetes (palmitate diet)
Male PPAR ß/ơ knockout mice and wildtype (PPAR ß/ơ +/+) littermates.
Applications
- Fatty acids, glucose and specific markers measu- rement in serum and tissues (white adipose tissue, blood, hepatocytes).
- Glucose Tolerance Test (GTT).
- Insulin Tolerance Test (ITT).
- Piruvate Tolerance Test (PTT).
- Biochemical and biomolecular techniques. EMSA: transcription factors assessment.
