Experimental models




Liver diseases (injury, fibrosis, cirrhosis and cancer)


In vivo

Model references

Fernández-Varo G et al. Hepatology. 2020

Hepatocellular carcinoma (HCC) in rat and mouse by chronic administration of diethylnitrosamine (DEN) or direct intrahepatic injection of liver cancer cells


  • Investigation of signaling pathways and possible therapeutic targets involved in liver injury, inflammation, fibrosis and cancer.
  • Investigation of the therapeutic effects of different nanoparticles and biomaterials (cerium, carbon and polymeric nanoparticles) on liver fibrosis and cancer.
  • Investigation of the therapeutic effects of cell implants and tissue engineering on liver regeneration and fibrosis regression.
  • Selective gene therapy or sh/siRNA gene silencing to macrophages, hepatocytes, and endothelial cells.
  • Lipidomic studies using gas chromatography-mass spectrometry.
  • Study of insulin resistance, obesity and hypertrigliceridemia,
  • Hemodynamic studies (cardiac output, mean arterial and portal pressure).
  • Study of hydrosaline balance, liver and renal function, and excretion.
  • Vascular biology analyses: Angiography, lymphangiography, vascular permeability, retina angiogenesis and vascular casting in mouse and rat.
  • Embryonic vascular assessment in mouse.
  • Vascular casting in mouse and rat
  • Measurement of vascular density in response to anti-angiogenic treatment.

Principal investigators

Wladimiro Jiménez, Pedro Melgar-Lesmes.

Model relevance

The use of these pre-clinical models allows evaluating the possible clinical applicability of new drugs or therapies using novel drugs, functionalized nanoparticles or biomaterials.

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