Area
Musculoskeletal System and Connective TissueIndication
Systemic connective tissue disorders: Giant cell arteritis with polymyalgia rheumatic and other giant cell arteritisSystem
In vitroEx vivo
Model references
Front Immunol. 2018 Apr 20;9:809;
Ann Rheum Dis. 2017 Sep;76(9):1624-1634;
Ann Rheum Dis. 2016 Jun; 75 (6):1177-86
Giant cell artheritis: model from epicraneal artery (10-15 cm control/disease pair).
Applications
- Translatable model to other vasculitis and vasculo- pathies.
- Disease vs Control comparison studies.
- Drugs, compounds and treatment combinations test.
- Molecular biology studies and biochemical tests: Proliferation, migration, regeneration, matrix cons- triction, microenvironment studies, gene and protein expression, histopathology, immunofluorescence, optical and confocal microscopy, cytometry.
Model advantages
Innovative and non-invasive model.
