Experimental models

Area

Ear and Mastoid Process

Indication

Other disorders of the ear: Presbycusis (Age-Related Hearing Loss)

System

In vivo

Model references

J Am Soc Nephrol. 2018 Jun; 29 (6):1624-1635

Double KO LAT2-TAT1 mice: dKO Slc7a8/Slc3a2 -/-.

Applications

  • Molecular basis of ARHL.
  • Disease development and stages.
  • Phenotypic studies of auditory system.
  • Cytoarchitecture of inner ear.
  • Cell type specific biomarkers study.
  • Syte-directed mutagenesis studies.
  • Molecular biology techniques from animal tissue: WB, PCR, cellular localization studies.
  • High throughput techniques (omic studies, proteo- mics, transcriptomics) from mouse tissue.

Principal investigators

Virginia Nunes, Manuel Palacín.

Other group publications

PubMed publications.

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