Applications

• Investigation of signaling pathways and possible therapeutic targets involved in liver injury, inflammation, fibrosis and cancer.
• Investigation of the therapeutic effects of different nanoparticles and biomaterials (cerium, carbon and polymeric nanoparticles) on liver fibrosis and cancer.
• Investigation of the therapeutic effects of cell implants and tissue engineering on liver regeneration and fibrosis regression.
• Selective gene therapy or sh/siRNA gene silencing to macrophages, hepatocytes, and endothelial cells.
• Lipidomic studies using gas chromatography-mass spectrometry.
• Study of insulin resistance, obesity and hypertrigliceridemia,
• Hemodynamic studies (cardiac output, mean arterial and portal pressure).
• Study of hydrosaline balance, liver and renal function, and excretion.
• Vascular biology analyses: Angiography, lymphangiography, vascular permeability, retina angiogenesis and vascular casting in mouse and rat.
• Embryonic vascular assessment in mouse.
• Vascular casting in mouse and rat.
• Measurement of vascular density in response to anti-angiogenic treatment.