Area
Nervous SystemIndication
Alzheimer diseaseSystem
In vivo5XFAD (B6SJL)
Applications
- Study of molecular and biochemical characteristics of the disease
- AD drug evaluation from phenotype and molecular point of view
- Drug validation for AD and other dementias
Principal investigators
Mercè Pallàs, Christian Griñán-FerréModel relevance
The model shows a clear cognitive decline, characteristic AD hallmarks, neuroinflammation and epigenetic changes. Likewise, our group has developed research on epigenetic alterations, endoplasmic reticulum stress and autophagy processes.
