Area
GastrointestinalIndication
Liver diseases (injury, fibrosis, cirrhosis and cancer)System
In vitroModel references
Cell Physiol Biochem. 2013;32(5):1125-36. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H550-5.
AC16 human cardiomyocyte cells
Applications
- Molecular biology assays in response to treatments with drugs, gene therapy or functional nanoparticles.
- Cell re-programming (knock-in and knock-out).
- Cell migration assays.
- Cell proliferation and viability assays.
- Cell adhesion assays.
- Cell culture in hypoxic conditions.
- Oxidative stress analysis.
- Induction of Fatty acid accumulation and measurements by gas chromatography and mass spectrometry.
Principal investigators
Wladimiro Jiménez, Pedro Melgar-Lesmes.Model relevance
Well-established cell lines representative for every hepatic cell subpopulation for the study of signaling pathways affected by different treatments and to assess toxicity and effectivity of novel biomaterials or nanotherapeutics.
