IndicationAutism Spectrum Disorder
Zebrafish ywhaz KO model developed using CRISPR/Cas9
- Behavioural experiments.
- Whole brain imaging using GCaMP6 marker.
- In situ hybridization to study gene expression during development and adulthood
Principal investigatorsBru Cormand Rifà, Noèlia Fernàndez-Castillo.
This model allows us to study the effect of loss of YWHAZ function on neural development and behaviour using different molecular and behavioural approaches and, therefore, characterize YWHAZ missfunctioning contribution to Autism Spectrum Disorder.