Area
Nervous SystemIndication
Autism Spectrum DisorderSystem
In vivoZebrafish ywhaz KO model developed using CRISPR/Cas9
Applications
- Behavioural experiments.
- Whole brain imaging using GCaMP6 marker.
- In situ hybridization to study gene expression during development and adulthood
Principal investigators
Bru Cormand Rifà, Noèlia Fernàndez-Castillo.Model relevance
This model allows us to study the effect of loss of YWHAZ function on neural development and behaviour using different molecular and behavioural approaches and, therefore, characterize YWHAZ missfunctioning contribution to Autism Spectrum Disorder.
