IndicationAutism Spectrum Disorder
Zebrafish rbfox1 sa15940 KO model from the Zebrafish Mutation Project, Sanger Institute
- Behavioural experiments.
- Whole brain imaging using GCaMP6 marker.
- In situ hybridization to study gene expression during development and adulthood.
Principal investigatorsBru Cormand Rifà, Noèlia Fernàndez-Castillo
This model allows us to study the effect of loss of RBFOX1 function on neural development and behaviour using different molecular and behavioural approaches and, therefore, characterize RBFOX1 missfunctioning contribution to Autism Spectrum Disorder and aggressive behaviour.