Experimental models

Area

Nervous System

Indication

Alzheimer disease

System

In vivo

The Senescence Accelerated Mouse-Prone 8 (SAMP8)

Applications

  • Study of molecular and biochemical characteristics of the disease
  • AD drug evaluation from phenotype and molecular point of view
  • Drug validation for AD and other dementias

Principal investigators

Mercè Pallàs, Christian Griñán-Ferré

Model relevance

The model shows a clear cognitive decline, characteristic AD hallmarks, neuroinflammation and epigenetic changes. Likewise, our group has developed research on epigenetic alterations, endoplasmic reticulum stress and autophagy processes.

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