Area

Opthalmology

Indication

Dry Eye, Keratoconjuctivitis, glaucoma and ocular hypertension, ocular pain

System

In vitro

Model references

TM cells:
Sci Rep. 2017 Mar 28;7(1):452;
SC cells:
Prog Retin Eye Res. 2015 Jan;44:86-98;
Exp Eye Res. 2014 Oct; 127:224-35;
Sci Rep. 2019 Apr 1; 9 (1):5392

Request a service with this experimental model

Ocular cell lines: Trabecular Meshwork (TM) cells and Schlemm’s canal endothelial cells (SC) derived from a human normotensive patient

Applications

To study cellular aspects of these cells participa- ting and regulating the passage of aqueous humor through the conventional route.
To decipher molecular mechanisms of Schlemm’s Canal Pore formation and its relationship with glau- coma disease.
Molecular biology techniques: western blot, calcium free measurement, immunofluorescence (subcellular localization studies), gene expression analysis.

Principal investigators

Xavier Gasull, David Soto, Nuria Comes.

Other group publications

X. Gasull at PubMed.
D. Soto at PubMed.
Nuria Comes at PubMed.

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