Human liver perfusion systems

Applications

Investigation of the effects of novel drugs, adenovirus or nanoparticle therapies in a milieu that retains the architecture, interactions, and multicellular characteristics of the healthy and cirrhotic hepatic tissue using PCLS. Comparison between species.
Hepatotoxicity studies.
Cell distribution and ultrastructural analysis of treatment with nanoparticles.
Evaluation of the dose-effect response of a new treatment in human hepatic cells.

Principal investigators

Wladimiro Jiménez, Pedro Melgar-Lesmes.

Model relevance

Well established pre-clinical tool to evaluate toxicity, therapeutic efficacy and dose-response of new drugs or functionalized nanoparticles in humans, and also in rats or mice.

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