Experimental models

Area

Cardiovascular

Indication

Cardiomyopathy

System

In vitro

Model references

Int J Cardiol. 2014 Jun 1; 174(1):110-8;
Dis Model Mech. 2015 Sep;8(9):1081-91

Human cardiac AC16 cell line: Fusion of primary ventricular cells with SV-40 transformed fibroblasts (not transferable cell line)

Applications

  • Deciphering molecular markers of cardiac disorders.
  • Test of therapeutic candidates.
  • Gene transfection.
  • Biochemical and biomolecular tests from cells and supernatants: gene expression (RT-PCR, qPCR), nuclear fractionation, protein expression and protein phosphorylation (WB), enzyme activity.
  • Cell viability studies.

Principal investigators

Manuel Vázquez-Carrera.

Other group publications

PubMed publications.

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