Experimental models

Area

Endocrine, Nutritional and Metabolic Diseases

Indication

Cystinuria

System

In vivo

Model references

J Am Soc Nephrol. 2018 Jun; 29 (6):1624-1635

Double KO LAT2-TAT1 mice: DKO Slc7a8/Slc3a2 model

Applications

  • Aminoaciduria studies.
  • Renal transporters study.
  • Molecular basis of renal reabsorption on different experimental diets.
  • Phenotypic studies.
  • Urinary bladder calculi quantification by X- ray analysis.
  • Metabolites studies from urine and blood.
  • Molecular Biology techniques from animal tissue: WB, PCR, IP, IC.
  • High throughput techniques (omic studies, proteo- mics, transcriptomics) from mouse tissue.
  • Test of drug candidates.

Principal investigators

Virginia Nunes Martínez, Manuel Palacín, Antonio Zorzano.

Other group publications

PubMed publications.

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