Area
OpthalmologyIndication
Dry Eye, Keratoconjuctivitis, glaucoma and ocular hypertension, ocular painSystem
In vivoModel references
Pain. 2015 Mar;156(3):483-95;
Pain. 2016 Feb;157(2):399-417;
Eur J Pharmacol. 2007 Jul 12; 567 (1-2):145-8;
Exp Eye Res. 2011 Mar; 92 (3):221-6
Animal models (mouse, rat and rabbit) of ocular pain by applying painful or pruritic substances in the ocular surface
Applications
- To study ocular pain after inflammation, injury or dry eye diseases.
- Topical application of substances to decipher neural mechanisms regulating intraocular pressure and ion K+ and Cl– channels that regulate contraction, shape and cell volume in trabecular cells that control aqueous humor flow and intraocular pressure in the eye.
- Understand the sensory ocular pathophysiology.
Examples
Ocular pain tests
- Blinking test.
- Thermal / mechanical sensitivity.
- Lacrimation (tear secretion measurement).
Principal investigators
Xavier Gasull, David Soto, Nuria Comes.Other group publications
X. Gasull at PubMed.
D. Soto at PubMed.
Nuria Comes at PubMed.
