Area
Ear and Mastoid ProcessIndication
Diseases of the Inner Ear: Disorders of vestibular function, vertiginous syndromesSystem
In vivoModel references
Arch Toxicol. 2019 Feb; 93 (2):417-434;
J Assoc. Res Otolaryngol. 2019 Jul 11;
Toxicol Sci. 2017 Mar 1;156(1):109-122;
Dis Model Mech. 2015 Oct 1;8(10):1323-37;
Neurotoxicology. 2017 May;60:1-9
Animal model of auditive and vestibular dysfunction: 3,3’-iminodipropionitrile (IDPN) and streptomycin ototoxic exposure in mou- se and rat.
Applications
- Neurotoxicity assessment.
- Regeneration studies.
- Behavioral evaluation of auditive and vestibular dysfunction.
- Drugs and chemicals testing.
- Histopathologic analysis of vestibular system: identification of molecular targets in the vestibular periphery.
- Vestibular toxicology and pharmacology.
- Histology and gene expression studies of the sen- sory epithelia of the inner ear: RT-PCR, RNA-seq, inmuno-histochemistry and confocal microscopy, scanning electron microscopy, transmission electron microscopy, light microscopy in semi-thin sections.
