Experimental models

Area

Gastrointestinal

Indication

Liver diseases (injury, fibrosis, cirrhosis and cancer)

System

In vitro

Model references

Cell Physiol Biochem. 2013;32(5):1125-36. Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H550-5.

AC16 human cardiomyocyte cells

Applications

  • Molecular biology assays in response to treatments with drugs, gene therapy or functional nanoparticles.
  • Cell re-programming (knock-in and knock-out).
  • Cell migration assays.
  • Cell proliferation and viability assays.
  • Cell adhesion assays.
  • Cell culture in hypoxic conditions.
  • Oxidative stress analysis.
  • Induction of Fatty acid accumulation and measurements by gas chromatography and mass spectrometry.

Principal investigators

Wladimiro Jiménez, Pedro Melgar-Lesmes.

Model relevance

Well-established cell lines representative for every hepatic cell subpopulation for the study of signaling pathways affected by different treatments and to assess toxicity and effectivity of novel biomaterials or nanotherapeutics.

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