J Neurosci. 2019 Mar 27;39(13):2441-2458
5xFAD mouse model of Alzheimer disease
- New therapeutic strategies.
- Mechanisms of disease.
- To study amyloid loading and pathogenesis.
Principal investigatorsJordi Alberch, Albert Giralt
This is the best model in vivo that mimics amyloidosis in Alzheimer disease. This mouse model displays cognitive deficits, neuroinflammation and neurodegeneration as occurs in Alzheimer’s disease.