Area
Nervous SystemIndication
Alzheimer diseaseSystem
In vivoModel references
J Neurosci. 2019 Mar 27;39(13):2441-2458
5xFAD mouse model of Alzheimer disease
Applications
- New therapeutic strategies.
- Mechanisms of disease.
- To study amyloid loading and pathogenesis.
Principal investigators
Jordi Alberch, Albert GiraltModel relevance
This is the best model in vivo that mimics amyloidosis in Alzheimer disease. This mouse model displays cognitive deficits, neuroinflammation and neurodegeneration as occurs in Alzheimer’s disease.
