Area
Musculoskeletal System and Connective TissueIndication
Systemic connective tissue disorders: Giant cell arteritis with polymyalgia rheumatic and other giant cell arteritisSystem
In vitroEx vivo
Model references
Ann Rheum Dis. 2017 Sep; 76 (9):1624-1634
Coculture models of peripheral blood mononuclear cells (PBMCs), lymphocytes, monocytes and vascular smooth muscle cells.
Applications
- Translatable model to other vasculitis and vasculo- pathies.
- Disease vs Control comparison studies.
- Drugs, compounds and treatment combinations test.
- Molecular biology studies and biochemical tests: Proliferation, migration, regeneration, matrix cons- triction, microenvironment studies, gene and protein expression, histopathology, immunofluorescence, optical and confocal microscopy, cytometry.
Model advantages
Innovative and non-invasive model.
