Experimental models

Area

Nervous System

Indication

Alzheimer disease

System

In vivo

Model references

J Neurosci. 2019 Mar 27;39(13):2441-2458

5xFAD mouse model of Alzheimer disease

Applications

  • New therapeutic strategies.
  • Mechanisms of disease.
  • To study amyloid loading and pathogenesis.

Principal investigators

Jordi Alberch, Albert Giralt

Model relevance

This is the best model in vivo that mimics amyloidosis in Alzheimer disease. This mouse model displays cognitive deficits, neuroinflammation and neurodegeneration as occurs in Alzheimer’s disease.

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