{"id":25545,"date":"2026-07-15T17:42:13","date_gmt":"2026-07-15T15:42:13","guid":{"rendered":"https:\/\/www.fbg.ub.edu\/?page_id=25545"},"modified":"2026-07-15T18:10:21","modified_gmt":"2026-07-15T16:10:21","slug":"arabidopsis-mc1-as-a-potent-disaggregase-of-neuropathological-aggregates","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/es\/que-hacemos\/tecnologias-materiales-y-licencias\/tecnologias-para-licenciar\/arabidopsis-mc1-as-a-potent-disaggregase-of-neuropathological-aggregates\/","title":{"rendered":"Arabidopsis MC1 as a potent disaggregase of neuropathological aggregates"},"content":{"rendered":"<h3>Executive summary<\/h3>\n<p>A research group, with wide experience on immunology, has generated a novel therapeutic solution for neurodegenerative disease by utilizing Arabidopsis Metacaspase I (AtMC1) to break down pathological protein aggregates in the central nervous system.<\/p>\n<p>The group is looking for a license, but other collaborations may be considered.<\/p>\n<h3>Introduction<\/h3>\n<p>NDDs are characterized by progressive neuron loss and pathological protein aggregation which affect millions globally.<\/p>\n<p>Current therapies mainly address symptoms, not the root cause of NDDs<\/p>\n<h3>Description<\/h3>\n<ul>\n<li>Design and test efficient AtMC1 variants using synthetic biology and protein engineering against aggregates linked to various NDDs (e.g., Alzheimer&#8217;s, Huntington\u2019s).<\/li>\n<li>Potential to revolutionize early-stage NDD treatment and improve patients&#8217; lives.<\/li>\n<li>Transfer technology to the pharmaceutical industry to accelerate clinical trials and market introduction.<\/li>\n<\/ul>\n<h3><strong>Current stage of development<\/strong><\/h3>\n<p><a href=\"https:\/\/www.fbg.ub.edu\/que-fem\/tecnologies-materials-llicencies\/tecnologies-per-llicenciar\/arabidopsis-mc1-as-a-potent-disaggregase-of-neuropathological-aggregates\/attachment\/ubtt0492-e_imagte-secundaria\/\" rel=\"attachment wp-att-25531\"><img loading=\"lazy\" decoding=\"async\" class=\" wp-image-25531 alignleft\" src=\"http:\/\/www.fbg.ub.edu\/wp-content\/uploads\/2026\/07\/UBTT0492-E_Imagte-secundaria-380x112.png\" alt=\"\" width=\"691\" height=\"204\" srcset=\"https:\/\/www.fbg.ub.edu\/wp-content\/uploads\/2026\/07\/UBTT0492-E_Imagte-secundaria-380x112.png 380w, https:\/\/www.fbg.ub.edu\/wp-content\/uploads\/2026\/07\/UBTT0492-E_Imagte-secundaria-768x227.png 768w, https:\/\/www.fbg.ub.edu\/wp-content\/uploads\/2026\/07\/UBTT0492-E_Imagte-secundaria.png 900w\" sizes=\"auto, (max-width: 691px) 100vw, 691px\" \/><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Executive summary A research group, with wide experience on immunology, has generated a novel therapeutic solution for neurodegenerative disease by&#8230;<\/p>\n","protected":false},"author":2,"featured_media":25536,"parent":1399,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-tecnologies.php","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-25545","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/25545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/comments?post=25545"}],"version-history":[{"count":4,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/25545\/revisions"}],"predecessor-version":[{"id":25556,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/25545\/revisions\/25556"}],"up":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/1399"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/media\/25536"}],"wp:attachment":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/media?parent=25545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}