A multidisciplinary research group with wide experience in medicinal chemistry and in the synthesis of compounds to treat neurological diseases, has designed, synthesized and pharmacologically characterized a set of compounds that show neuroprotective activity.<\/p>\n
Neurodegenerative disorders, such as Alzheimer\u2019s Disease (AD), Parkinson\u2019s Disease (PD), and Huntington\u2019s Disease (HD), represent a growing global health crisis. Such conditions significantly reduce quality of life, increase dependency and entail high economic costs, affecting severely to both patients, caregivers, and health systems. As an example, neurodegenerative diseases cost US$655,000 million in medical expenses and economy losses; more specifically, PD total annual costs are US$55,000 million and are expected to rise around 50% in the next 10 years. In Spain, the average cost per AD patient is \u20ac42k annually.<\/p>\n
Therapeutic options are currently limited and unable to stop or slow neurodegeneration. As populations age exponentially, the need for effective neuroprotective therapies has never been more urgent.<\/p>\n
The neurodegenerative disease market is projected to grow from US$ 55,000 million in 2024 to US$99,000 million by 2032. Moreover, the neurodegenerative drugs segment alone reached US$ 36.000 million in 2021 and shall hit US$75,000 million by 2031.<\/p>\n
Given the rapidly increasing patient population, the high socioeconomic burden, and the limitations of current treatments, there is an urgent need to develop innovative neuroprotective drugs that can go beyond symptomatic relief and preserve neuronal function for conditions such as AD, PD, and HD.<\/p>\n
35 compounds with a 2-imidazoline structure have been synthesized and characterized within a Markush Formula. After a screening cascade (ADME) two compounds were selected and characterized in a neuropharmacokinetic study showing a good BBB penetration and safe parameters. The treatment with these compounds of a murine model of AD, 5xFAD, led to a cognitive improvement and enhanced condition of the diseased animals, approaching the parameters observed in the control animals.<\/p>\n
Next steps are to determine ADME and safety values of a higher number of the set of compounds in order to perform a screening cascade.<\/p>\n
Pharmacological studies will follow with the selected compounds to increase data related to neuroprotective activity. Also, MTD studies shall be done.<\/p>\n
Neuroprotective studies will be performed in those murine models appropriate to evaluate the use of the selected compounds in AD. Determination of hallmarks of AD.<\/p>\n","protected":false},"excerpt":{"rendered":"
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