{"id":2182,"date":"2017-09-15T19:01:24","date_gmt":"2017-09-15T18:01:24","guid":{"rendered":"http:\/\/161.116.26.48\/investigadores\/grupos-investigacion-ub\/in-vitro-alternative-testing-methodology\/"},"modified":"2017-11-24T13:49:50","modified_gmt":"2017-11-24T12:49:50","slug":"in-vitro-alternative-testing-methodology","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/es\/investigadores\/grupos-investigacion-ub\/in-vitro-alternative-testing-methodology\/","title":{"rendered":"In vitro alternative testing methodology"},"content":{"rendered":"<h3>Introduction<\/h3>\n<p>The research group on Cell Membrane Surfactant Interactions is a R&amp;D unit at the University of Barcelona specialized in the <strong>development of <em>in vitro<\/em> methodology<\/strong> for analyzing safety and toxicology of ingredients and products aimed to Health and Personal Care.<\/p>\n<p>The team also works in the development of <strong>colloids systems for<\/strong> <strong>drug delivery<\/strong> applications.<\/p>\n<h3>WHAT WE DO<\/h3>\n<h4>Services<\/h4>\n<ul>\n<li><strong>In vitro Safety &amp; Toxicology analysis<\/strong><\/li>\n<li><strong>Anti-Ox\u00a0activity<\/strong><br \/>\nAssessment of Anti-Ox activity in cellular models and cytotoxicity;<br \/>\nHaemolysis Inhibition Assay; Lipid Peroxidation Inhibition Assay; Cytotoxicity Protection Assay.<\/li>\n<li><strong>Colloids Systems Development<br \/>\n<\/strong>Physico-Chemical Characterization<br \/>\n<em>Morphology. (TEM, Cryo-TEM); Particle size (DLS)<br \/>\n<\/em><strong>In vitro Biocompatibility<br \/>\n<\/strong><em>Hemocompatibility. Cytotoxicity. Blood coagulation. Protein interactions<br \/>\n<\/em><strong>Drug delivery<\/strong><\/li>\n<\/ul>\n<h3>FOR WHOM WE WORK<\/h3>\n<h4>Industrials sectors<\/h4>\n<ul>\n<li>Cosmetics &amp; Personal Care<\/li>\n<li>Pharmaceutical \u2013 Biotechnology<\/li>\n<li>In Vitro Tox \u2013 Diagnosis<\/li>\n<\/ul>\n<h3>RESEARCH<\/h3>\n<h4>Research projects<\/h4>\n<ul>\n<li>In vitro models adaption for safety assessment of colloids particles at micro and nanometric scale. MAT 2012-38047-C02-01.<\/li>\n<li>Multifunctional Nanomaterials: Strategies to increase selectivity in solid tumors therapies.<\/li>\n<li>Derived Nanomaterials as new therapeutic and immunogenic strategy in glioblastoma treatment.<\/li>\n<li>Fitting alternative methods to assess skin toxic effects induced by nanomaterials.<\/li>\n<\/ul>\n<h3>RESULTS<\/h3>\n<h4>Publications<\/h4>\n<ul>\n<li><strong>PEGylated and poloxamer-modified chitosan nanoparticles incorporating a lysine-based surfactant for pH-triggered doxorubicin release<\/strong>. Scheeren LE, Nogueira DR, Macedo LB, Vinardell MP, Mitjans M, Infante MR, Rolim CM. <em>Colloids Surf B Biointerfaces<\/em>. 2016 Feb 1;138:117-27.<\/li>\n<li><strong>Photoprotection by Punica granatum seed oil nanoemulsion entrapping polyphenol-rich ethyl acetate fraction against UVB-induced DNA damage in human keratinocyte (HaCaT) cell line<\/strong>. Baccarin T, Mitjans M, Ramos D, Lemos-Senna E, Vinardell MP. <em>J Photochem Photobiol<\/em> B. 2015 Dec;153:127-36.<\/li>\n<li><strong>Interactions of PLGA nanoparticles with blood components: protein adsorption, coagulation, activation of the complement system and hemolysis studies<\/strong>. Fornaguera C, Calder\u00f3 G, Mitjans M, Vinardell MP, Solans C, Vauthier C. <em>Nanoscale<\/em>. 2015 Apr 14;7(14):6045-58.<\/li>\n<li><strong>Erythrocytes and cell line-based assays to evaluate the cytoprotective activity of antioxidant components obtained from natural sources<\/strong>. Botta A, Mart\u00ednez V, Mitjans M, Balboa E, Conde E, Vinardell MP. <em>Toxicol In Vitro<\/em>. 2014 Feb;28(1):120-4.<\/li>\n<li><strong>Establishment of an in vitro photoassay using THP-1 cells and IL-8 to discriminate photoirritants from photoallergens<\/strong>. Mart\u00ednez V, Galbiati V, Corsini E, Mart\u00edn-Venegas R, Vinardell MP, Mitjans M. <em>Toxicol In Vitro<\/em>. 2013 Sep;27(6):1920-7.<\/li>\n<li><strong>In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles<\/strong>. Nogueira DR, Tavano L, Mitjans M, P\u00e9rez L, Infante MR, Vinardell MP. Biomaterials. 2013 Apr;34(11):2758-72.<br \/>\n<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed?term=(Vinardell%20MP%5BAuthor%5D)%20AND%20Mitjans%20M%5BAuthor%5D\" target=\"_blank\" rel=\"noopener\">More publications<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Introduction The research group on Cell Membrane Surfactant Interactions is a R&amp;D unit at the University of Barcelona specialized in&#8230;<\/p>\n","protected":false},"author":1,"featured_media":3979,"parent":1469,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-grupsrecerca.php","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-2182","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/2182","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/comments?post=2182"}],"version-history":[{"count":4,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/2182\/revisions"}],"predecessor-version":[{"id":3982,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/2182\/revisions\/3982"}],"up":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/pages\/1469"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/media\/3979"}],"wp:attachment":[{"href":"https:\/\/www.fbg.ub.edu\/es\/wp-json\/wp\/v2\/media?parent=2182"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}