{"id":13857,"date":"2022-04-27T09:03:21","date_gmt":"2022-04-27T07:03:21","guid":{"rendered":"http:\/\/161.116.26.48\/ambitos\/salud-y-ciencias-vida\/integrative-biochemistry-metobolic-disorders\/"},"modified":"2022-04-27T09:09:29","modified_gmt":"2022-04-27T07:09:29","slug":"integrative-biochemistry-metobolic-disorders","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/es\/ambitos\/salud-y-ciencias-vida\/integrative-biochemistry-metobolic-disorders\/","title":{"rendered":"Integrative BioChemistry & Metobolic Disorders"},"content":{"rendered":"

Presentation of the group<\/h3>\n

The research group carries out the integrated analysis of biological systems by combining techniques from biochemistry, cellular and molecular biology and bioinformatics. Main research Lines:<\/p>\n

– Metabolomics and flowmetry<\/strong>: Characterization of the metabolic adaptations associated with the presence of multifactorial diseases.<\/p>\n

– Cancer therapy<\/strong>: Design of antitumor therapies based on inhibition of different key points of cancer cell metabolism, and characterization of the effect of different compounds with antitumor activity.<\/p>\n

– Analysis of the control and regulation of biochemical systems<\/strong>: Development and application of software for the analysis and modelling of metabolic pathways, using kinetic or stochastic methods.<\/p>\n

– Evaluation of natural products<\/strong>: Characterization of the efficacy of derivatives of natural products and agro-food residues as products with high added value (food supplements, therapeutic treatments of different diseases,…).<\/p>\n

WHAT WE DO<\/h3>\n

Services<\/h4>\n
    \n
  • Metabolic and flow analysis of biological samples.<\/li>\n
  • Evaluation of the biological activity of new compounds with antitumor activity.<\/li>\n
  • In-vivo tests with animal models.<\/li>\n
  • Modelling of biochemical systems.<\/li>\n<\/ul>\n

    FOR WHOM WE WORK<\/h3>\n

    Industrial sectors<\/h4>\n
      \n
    • Health and Biotechnology<\/li>\n
    • Multifactorial diseases<\/li>\n
    • Preclinical tests<\/li>\n
    • Validation of pharmacological targets<\/li>\n
    • Nutrition<\/li>\n
    • Natural products<\/li>\n
    • Functional Foods<\/li>\n
    • Environment<\/li>\n
    • Agro-food and agroforestry waste<\/li>\n
    • Subproducts of vine and olive grove<\/li>\n<\/ul>\n

      Clients<\/h4>\n
        \n
      • Biocross<\/li>\n
      • University of Kentucky<\/li>\n
      • Tavargenix<\/li>\n
      • Biomaslinic\u00a0 Digna Biotech<\/li>\n
      • IMIM<\/li>\n<\/ul>\n

        RESEARCH<\/h3>\n

        (2015-2019) MOGLYNET<\/em><\/strong> Modulation of glycolitic flux as a new approach for treatment of artherosclerosis and plaque stabilization: a multidisciplinary study<\/em>.\u00a0 P.Inv. Marta Cascante. H2020, EUComission.<\/p>\n

        (2015-2019) HaemMetabolome<\/em><\/strong>\u00a0 Deciphering the Metabolism of Haematological Cancers.<\/em> P.Inv. Marta Cascante. H2020, EU Comission<\/p>\n

        (2015-2018) PhenoMeNal<\/em><\/strong>: a comprehensive and standarised e-infrastructure for analysing medical metabolic phenotype data. <\/em>P.Inv. M Cascante. H2020, EU Comission.<\/p>\n

        (2012-2015) COSMOS. <\/em><\/strong>Developing an efficient e-infrastructure, standards and data-flow for metabolomics and its interface to biomedical and life science e-infrastructures in Europe and worldwide<\/em> P. Inv. M. Cascante. 7FP, EU Comission.<\/p>\n

        (2015-2017) Red de medicina de sistemas e integraci\u00f3n de tecnolog\u00edas \u00f3micas: Transcript\u00f3mica, prote\u00f3mica, metabol\u00f3mica y flux\u00f3mica <\/em>
        \nP.Inv. M Cascante. Ministerio de Econom\u00eda y Competividad.<\/p>\n

        (2015-2017) An\u00e1lisis de la reprogramaci\u00f3n metab\u00f3lica metast\u00e1sica en la b\u00fasqueda de nuevas estrategias terap\u00e9uticas en c\u00e1ncer .\u00a0 P.Inv. M Cascante. Ministerio de Econom\u00eda y Competividad.<\/p>\n

        RESULTS<\/h3>\n

        Patents & Tech Transfer Activities<\/h4>\n
          \n
        • Grape Polyphenols as solar protectors (ESP, N\u00ba 9901958)<\/li>\n
        • Flavones and Cysteine Conjugates \u00a0\u00a0(ESP, N\u00ba 200102081)<\/li>\n
        • llamin\u00e0ria Algae Extract as anti-proliferative agents
          \n(ESP, N\u00ba 200300858)<\/li>\n
        • Triterpene derivatives as anti-proliferative agents
          \n(POR\/USA,N\u00ba 20091000049475)<\/li>\n
        • Use of Grape Fibre for Intestinal Cancer treatment
          \n(ESP, N\u00ba 201230935)<\/li>\n
        • Preclinical studies for of antitumor candidates.<\/li>\n
        • Study of the inhibition of transketolase with the therapeutic target.<\/li>\n
        • In vivo study of the antitumor effect of maslinic acid on Colorectal tumours.<\/li>\n
        • Metabolomic flux modelling of the glucose from experimental properties with 13<\/sup>C.<\/li>\n
        • Metabolomic analysis of ictus patients samples: looking for new biomarkers.<\/li>\n<\/ul>\n

          Publications<\/h4>\n

          T\u00e9nyi A, de Atauri P, G\u00f3mez-Cabrero, D, Cano I, Clarke K, Falciani F, Cascante M, Roca J and Maier D. 2016.\u00a0ChainRank, a chain prioritisation method for contextualisation of biological networks<\/em><\/strong>.\u00a0BMC Bioinformatics, 17:17<\/p>\n

          Cano I, Selivanov V, G\u00f3mez-Cabrero D, Tegn\u00e9r J, Roca J, Wagner PD and Cascante M. 2014. Oxygen pathway modeling estimates high reactive oxygen species production above the highest permantent human habitation<\/em><\/strong>. <\/em>PLoS ONE, 9(11).<\/p>\n

          Guzm\u00e1n S, Marin S, Miranda A, Selivanov VA, Centelles JJ, Harmancey R, Smith F, Turkieh A, Durocher Y, Zorzano A, Rouet P and Cascante M. 2014. 13<\/sup>C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes<\/em><\/strong>. BMC Systems Biology, 8:109<\/p>\n","protected":false},"excerpt":{"rendered":"

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