{"id":3858,"date":"2017-09-15T18:59:04","date_gmt":"2017-09-15T17:59:04","guid":{"rendered":"http:\/\/161.116.26.48\/researchers\/research-groups-of-the-ub\/sistemes-cellulars-in-vitro\/"},"modified":"2017-11-23T11:16:03","modified_gmt":"2017-11-23T10:16:03","slug":"sistemes-cellulars-in-vitro","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/en\/researchers\/research-groups-of-the-ub\/sistemes-cellulars-in-vitro\/","title":{"rendered":"Sistemes cel\u00b7lulars in vitro"},"content":{"rendered":"

Presentaci\u00f3<\/h3>\n

Celltec \u00a0UB \u00a0\u00e9s \u00a0una \u00a0iniciativa \u00a0d\u2019un \u00a0col\u00b7lectiu \u00a0d\u2019investigadors \u00a0del \u00a0Departament \u00a0de Biologia Cel\u00b7lular de la Universitat de Barcelona. Celltec UB promou la innovaci\u00f3 i la transfer\u00e8ncia de tecnologia cel\u00b7lular i molecular i ofereix a les empreses el desenvolupament i la utilitzaci\u00f3 dels models cel\u00b7lulars in vitro <\/em>per al cribratge i els estudis d\u2019efic\u00e0cia, toxicitat, metabolisme, i mecanismes d\u2019acci\u00f3 dels seus productes. La seva gran experi\u00e8ncia amb empreses els hi ha perm\u00e8s estar acreditats amb el segell TECNIO que atorga la Generalitat de Catalunya a trav\u00e9s d\u2019ACCI\u00d3.<\/p>\n

QU\u00c8 FEM<\/h3>\n

Serveis<\/strong><\/h3>\n
    \n
  • S<\/em>c<\/em>r<\/em>eening <\/em>funcional massiu de compostos funcionals.<\/li>\n
  • Desenvolupament de cultius cel\u00b7lulars a partir de mostres biol\u00f2giques.<\/li>\n
  • Desenvolupament de sistemes cel\u00b7lulars in vitro <\/em>per a noves dianes funcionals.<\/li>\n
  • Estudis d\u2019efic\u00e0cia i seguretat de compostos per a dossiers regulatoris o comercials.<\/li>\n<\/ul>\n

    PER A QUI TREBALLEM<\/h3>\n

    Sectors industrials<\/h3>\n

    La gran versatilitat de les aplicacions dels sistemes cel\u00b7lulars \u00a0in \u00a0vitro \u00a0<\/em>permet \u00a0treballar \u00a0estretament amb les ind\u00fastries Farmac\u00e8utica, Cosm\u00e8tica, Aliment\u00e0ria i Veterin\u00e0ria.<\/p>\n

    Clients<\/h3>\n

    Advancell; Keramat; Antientropic; ApplicaCell; La Amarilla de Ronda; Dermofarm; Lucta; Leitat; Laboratoris Cinfa; Kemin; Rubinum; Idesa Parfums.<\/p>\n

    RECERCA<\/h3>\n

    L\u00ednies de recerca<\/h3>\n
      \n
    • Avaluaci\u00f3 i millora de biomaterials emprats en osteog\u00e8nesi i medicina regenerativa.<\/li>\n
    • Estudi de l\u2019epicardi embrional i les seves implicacions en la regeneraci\u00f3 card\u00edaca.<\/li>\n
    • Desenvolupament de nous models cel\u00b7lulars per screening <\/em>de productes actius.<\/li>\n
    • Paper dels proteoglucans de tipus sindec\u00e0 en el comportament cel\u00b7lular.<\/li>\n
    • Mecanismes de superviv\u00e8ncia i mort neuronal.<\/li>\n
    • Medicina regenerativa de la superf\u00edcie ocular.<\/li>\n<\/ul>\n

      Projectes de recerca<\/h3>\n
        \n
      • (2016-2018) \u00a0Identificaci\u00f3n \u00a0de \u00a0una \u00a0nueva \u00a0v\u00eda \u00a0implicada \u00a0en \u00a0el \u00a0desarrollo \u00a0del \u00a0epicardio embrionario a partir de los an\u00e1lisis de microarray de c\u00e9lulas aisladas in vivo. <\/em>(BFU2015-<\/em>6<\/em>8<\/em>1<\/em>3<\/em>5<\/em>-P)<\/em>. I.P. Ofelia Mart\u00ednez Estrada. MINECO<\/li>\n
      • (2016-2018) \u00a0Study \u00a0and \u00a0manipulation \u00a0of \u00a0the \u00a0embryonic \u00a0epicardium \u00a0program, \u00a0a \u00a0new approach for heart repair. <\/em>(<\/em>P<\/em>M<\/em>T2015A)<\/em>. I.P. Ofelia Mart\u00ednez Estrada. Fund. La Marat\u00f3 TV3<\/li>\n
      • (2015-2017) Se\u00f1alizaci\u00f3n mitocondrial retrograda dependiente de Mfn2 en neurodegene- raci\u00f3n. (SAF2014-59872-P). <\/em>I.P. Francesc X. Soriano Zaragoza. MINECO<\/li>\n
      • (2015-2017) Identificaci\u00f3n de las funciones del gen Wt1 en la enfermedad de Huntington. <\/em>(PRA2015A)<\/em>. I.P. Ofelia Mart\u00ednez Estrada. Fundaci\u00f3n Ram\u00f3n Areces<\/li>\n
      • (2012-2016) Wt1-heart: Identification of new targets of Wt1 during cardiovascular development <\/em>(Ref. PCIG10-GA-2011-303926). I.P. Manuel Reina del Pozo. FP7, EC<\/li>\n<\/ul>\n

        RESULTATS<\/h3>\n

        Activitats de transfer\u00e8ncia<\/h3>\n
          \n
        • S<\/em>c<\/em>r<\/em>eening <\/em>en sistemes cel\u00b7lulars de compostos umami.<\/li>\n
        • Assajos d\u2019avaluaci\u00f3 biol\u00f2gica i biocompatibilitat de materials cer\u00e0mics.<\/li>\n
        • Avaluaci\u00f3 de la capacitat transfectant de formulacions de DNA en nanopart\u00edcules.<\/li>\n
        • Desenvolupament de models cel\u00b7lulars in vitro <\/em>per al bioassaig de gonadotropines.<\/li>\n
        • Avaluaci\u00f3 de la capacitat antioxidant i de l\u2019efic\u00e0cia cosm\u00e8tica in vitro <\/em>de l\u2019Hidroxitirosol.<\/li>\n
        • Assessorament \u00a0i \u00a0validaci\u00f3 \u00a0experimental \u00a0de \u00a0productes \u00a0per \u00a0a \u00a0dermofarm\u00e0cia, \u00a0cosm\u00e8tica, terap\u00e8utica natural i diet\u00e8tica.<\/li>\n<\/ul>\n

          Publicacions rellevants<\/h3>\n
            \n
          • Angulo-Ib\u00e1\u00f1ez M, Rovira-Clav\u00e9 X, Granados-Ja\u00e9n A, Bradley D, Kim YC, Wang SM, Reina M and Espel E. 2015. E<\/em>r<\/em>k<\/em>5 contributes to maintaining the balance of cellular nucleotide levels and erythropoiesis. <\/em>Cell Cycle, 14(24)<\/li>\n
          • Martorell A, Segarra M, Reina M, Mart\u00ednez-Estrada OM and Soriano FX. 2015. M<\/em>itochondrial fragmentation in exocitotoxicity requires ROCK activation. <\/em>Cell Cycle, 14(9)<\/li>\n
          • Blanch \u00a0AR, \u00a0M\u00e9ndez \u00a0J, \u00a0Castel \u00a0S \u00a0and \u00a0Reina \u00a0M. \u00a02014. \u00a0Comparison \u00a0of \u00a0procedures \u00a0for \u00a0the extraction of supernatants and cytotoxicity tests in Vero cells, applied to assess the toxigenic potential of Bacillus spp. and Lactobacillus spp., intended for use as probiotic strains. <\/em>J Microbiological Methods, 103<\/li>\n
          • Martorell A, Segarra M, Mu\u00f1oz JP, Ginet V, Olloquequi J, P\u00e9rez-Clausell J, Palac\u00edn M, Reina M, Puyal J, Zorzano A and Soriano FX. 2014. M<\/em>fn2 downregulation in excitootoxicity causes mitochondrial dysfunction and delayed neuronal death. <\/em>The EMBO J, 33(20)<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

            Presentaci\u00f3 Celltec \u00a0UB \u00a0\u00e9s \u00a0una \u00a0iniciativa \u00a0d\u2019un \u00a0col\u00b7lectiu \u00a0d\u2019investigadors \u00a0del \u00a0Departament \u00a0de Biologia Cel\u00b7lular de la Universitat de Barcelona. Celltec…<\/p>\n","protected":false},"author":1,"featured_media":3778,"parent":1468,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-grupsrecerca.php","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3858","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/3858","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=3858"}],"version-history":[{"count":1,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/3858\/revisions"}],"predecessor-version":[{"id":3859,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/3858\/revisions\/3859"}],"up":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/1468"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/media\/3778"}],"wp:attachment":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=3858"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}