{"id":2183,"date":"2017-09-15T19:04:59","date_gmt":"2017-09-15T18:04:59","guid":{"rendered":"http:\/\/161.116.26.48\/researchers\/research-groups-of-the-ub\/interaccio-microbiota-epiteli-intestinal\/"},"modified":"2022-02-23T14:50:53","modified_gmt":"2022-02-23T12:50:53","slug":"interaccio-microbiota-epiteli-intestinal","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/en\/researchers\/research-groups-of-the-ub\/interaccio-microbiota-epiteli-intestinal\/","title":{"rendered":"Interacci\u00f3 de microbiota i epiteli intestinal"},"content":{"rendered":"

Presentaci\u00f3<\/h3>\n

El grup de recerca GUT MICROBIOTA-HOST INTERACTION forma part del grup consolidat \u201cBioqu\u00edmica Integrativa\u201d de la Universitat de Barcelona, adscrit a la xarxa SRG (SGR-1017) de grups de recerca de la Generalitat de Catalunya.<\/p>\n

\u00e9s tamb\u00e9 un grup integrant del Institut de Recerca de Biomedicina de la Universitat de Barcelona (IBUB) i de l\u2019Institut de recerca Sant Joan de Deu.<\/p>\n

La microbiota intestinal t\u00e9 un paper rellevant en la salut humana. Desequilibris en la seva composici\u00f3 estan associats a determinades malalties. Aquest grup, liderat per la Dra. Laura Baldom\u00e0 i la Dra. Josefa Badia, est\u00e0 centrat en l\u2019estudi dels mecanismes implicats en la interacci\u00f3\/ comunicaci\u00f3 \u00a0de la\u00a0microbiota amb \u00a0c\u00e8l\u00b7lules epitelials i immunes de la mucosa intestinal a trav\u00e9s de factors secretats, en especial ves\u00edcules extracel\u00b7lulars. Aquestes ves\u00edcules bacterianes poden difondre a trav\u00e9s del mucus intestinal i accedir a l\u2019epiteli, i son per tant, actors clau en la comunicaci\u00f3 amb l\u2019hoste. El coneixement derivat d\u2019aquesta recerca pot obrir noves aproximacions terap\u00e8utiques basades en postbi\u00f2tics.<\/p>\n

\u00a0<\/strong><\/p>\n

QU\u00c8 FEM<\/h3>\n

Serveis<\/h4>\n
    \n
  • Cultius bacterians. A\u00efllament I an\u00e0lisi de ves\u00edcules de soques probi\u00f2tiques i microbiota comensal com indicadors d\u2019efectivitat.\n

    models in vitro<\/em> d\u2019inflamaci\u00f3 intestinal.<\/li>\n

  • An\u00e0lisi de la capacitat antiinflamat\u00f2ria de probi\u00f2tics o f\u00e0rmacs en l\u2019intest\u00ed, mitjan\u00e7ant.<\/li>\n
  • An\u00e0lisi de la resposta immunit\u00e0ria i funci\u00f3 de barrera front bacteris o compostos qu\u00edmics, mitjan\u00e7ant models in vitro <\/em>(l\u00ednies cel\u00b7lulars humanes d\u2019epiteli intestinal, c\u00e8l\u00b7lules immunes).<\/em><\/li>\n
  • Estudi in vitro <\/em>de citotoxicitat cel\u00b7lular.<\/li>\n
  • An\u00e0lisi d\u2019expressi\u00f3 g\u00e8nica per RT-qPCR. An\u00e0lisis de micro-RNAs.<\/li>\n<\/ul>\n

     <\/p>\n

    PER A QUI TREBALLEM<\/h3>\n

    Sectors industrials<\/h4>\n

    Els probi\u00f2tics tenen gran acceptaci\u00f3 en la ind\u00fastria farmac\u00e8utica, veterin\u00e0ria i nutric\u00e8utica. Actualment, hi ha un inter\u00e8s creixent pels postbi\u00f2tics, definits com productes derivats de probi\u00f2tics generats durant el proc\u00e9s de fermentaci\u00f3. Dins d\u2019aquest grup s\u2019inclouen components cel\u00b7lulars dels bacteris, biomol\u00e8cules, metab\u00f2lits i factors bioactius secretats al medi. Les ves\u00edcules exportades per probi\u00f2tics o microbiota comensal compleixen les caracter\u00edstiques dels postbi\u00f2tics.<\/p>\n

    RECERCA<\/h3>\n

    L\u00ednies de recerca<\/h4>\n
      \n
    • Ves\u00edcules extracel\u00b7lulars de probi\u00f2tics I microbiota comensal:<\/li>\n<\/ul>\n

      – com a moduladors de la resposta immunit\u00e0ria I funci\u00f3 de barrera intestinal.<\/p>\n

      – identificaci\u00f3 de noves funcions amb potencial aplicaci\u00f3 a malalties infeccioses, \u00a0metab\u00f2liques o c\u00e0ncer<\/p>\n

      RESULTATS<\/h3>\n

      Publicacions rellevants<\/h4>\n
        \n
      • Diaz-Garrido N et al. Transcriptomioc microRNA profiling of dendritic cells in response to gut microbiota-secreted vesicles. Cells (2020) 9, 1534.<\/li>\n
      • Diaz-Garrido N et al. Membrane vesicles from the probiotic Nissle 1917 and gut resident Escherichia coli<\/em> strains distinctly modulate human dendritic cells and subsequent T cell responses. J. Funct. Foods<\/em> (2019) 61, 103495.<\/li>\n
      • Ca\u00f1as MA et al. Outer membrane vesicles from probiotic and commensal Escherichia coli <\/em>activate NOD1-mediated immune responses in intestinal epithelial cells. Front. Microbiol<\/em> (2018) 9, 498.<\/li>\n
      • Alvarez CS et al. Outer membrane vesicles and soluble factors released by probiotic Escherichia coli<\/em> Nissle 1917 and commensal ECOR63 enhance barrier function by regulating expression of tight junction proteins in intestinal epithelial cells. Front. Microbiol <\/em>(2016) 7, 1981.<\/li>\n
      • F\u00e1brega MJ et al. Activation of immune and defence responses in the intestinal mucosa by outer membrane vesicles of commensal and probiotic Escherichia coli strains. Front. Microbiol (2016) 7, 70.<\/li>\n<\/ul>\n

         <\/p>\n","protected":false},"excerpt":{"rendered":"

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