{"id":2143,"date":"2017-09-15T19:09:18","date_gmt":"2017-09-15T18:09:18","guid":{"rendered":"http:\/\/161.116.26.48\/researchers\/research-groups-of-the-ub\/design-and-development-of-therapeutic-peptides\/"},"modified":"2021-11-18T10:17:48","modified_gmt":"2021-11-18T08:17:48","slug":"design-and-development-of-therapeutic-peptides","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/en\/researchers\/research-groups-of-the-ub\/design-and-development-of-therapeutic-peptides\/","title":{"rendered":"Design and development of therapeutic peptides"},"content":{"rendered":"

Introduction<\/h3>\n

Since 2003, the Group of Therapeutic Peptides<\/strong> (University of Barcelona) is involved in the research & development of new peptide-based chemical entities, from the design to the preclinical proof-of-concept stages, with the long-term objective of developing them as future drugs and medicines.<\/p>\n

WHAT WE DO<\/h3>\n

Services<\/h3>\n
    \n
  • Design and synthesis of potential peptide-based therapeutic compounds.<\/li>\n
  • Purification, characterization, and structure elucidation of peptide-based compounds<\/li>\n
  • Mechanism of Action studies:\n
      \n
    • Fluorescence-based experiments, using covalently-labeled lipids and peptides<\/li>\n
    • Monolayers at the air\/water interface as a tool to study peptide and protein interaction with the membrane: insertion kinetics at constant pressure\/area, pressure\/area isotherms, surface potential measurement, and morphology changes determined by Brewster angle microscopy, and atomic force microscopy on solid support (Langmuir-Blodgett films).<\/li>\n
    • Preparation of liposomes (SUVs, LUVs, GUVs), characterization of size distribution by light-scattering and determination of Z-potential.<\/li>\n
    • Flow-cytometry and microscopy to identify cell damage<\/li>\n<\/ul>\n<\/li>\n
    • In vitro<\/em> and in vivo<\/em> proof of concept of new compounds (NCE) through integrated and multidisciplinary collaboration with other research groups within the University of Barcelona.<\/li>\n<\/ul>\n

      FOR WHOM WE WORK<\/h3>\n

      Industry Sectors<\/strong><\/h3>\n

      Research on the design and development of therapeutic peptides is of high interest for the Pharmaceutical & Drug, Cosmetic, Chemical, and Biotechnology industries.<\/p>\n

      RESULTS<\/h3>\n

      Transfer Activities<\/h3>\n

      Previous R+D+I contracts and consultancy services<\/strong><\/p>\n

        \n
      • Design and chemical synthesis of bioactive peptides and pseudopeptides (Method Pseudo).<\/li>\n
      • Development of novel peptide analogues for infectious disease applications.<\/li>\n
      • Consultancy on the substitution of formol as a fixative solution in human clinical samples.<\/li>\n<\/ul>\n

        Patents<\/strong><\/p>\n

        WO2020074405 <\/strong>– Polymyxin-based compounds useful as antibacterial agents<\/p>\n

        WO2014167160<\/strong> – Peptide compounds suitable for use as antibiotic agents.<\/p>\n

        WO2011054993<\/strong> – Peptides for the treatment of ocular hypertension and\/or glaucoma.<\/p>\n

        WO2008071594<\/strong> – Polypeptides with the capacity to entrap drugs.<\/p>\n

        Recent Publications<\/h3>\n
          \n
        • Cano, A.; Ettcheto, M.; Espina M.; L\u00f3pez-Machado, A.; Cajal, Y.; Rabanal F.; S\u00e1nchez-L\u00f3pez, E.; Camins, A.; Garc\u00eda M. L.; Souto, E. B. (2020) State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections. Journal of Nanobiotechnology<\/em>, 18, 156<\/li>\n
        • Rabanal*, Y. Cajal. Recent advances and perspectives in the design and development of polymyxins (2017) Natural Product Reports<\/em>, 34<\/em>, 886 – 908<\/li>\n
        • Rudilla, E. Fust\u00e9, Y. Cajal<\/u>, F. Rabanal, T. Vinuesa, M. Vi\u00f1as (2016) Synergistic Antipseudomonal effects of synthetic peptide AMP38 and carbapenems. Molecules<\/em>. 21, 122<\/li>\n
        • Rabanal*, A. Grau-Campistany, X. Vila-Farr\u00e9s, J. Gonz\u00e1lez-Linares, J. M. Borras, J. Vila, A. Manresa, Y. Cajal (2015) A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity. Scientific Reports<\/em>, 5, 10558<\/li>\n
        • Grau A., E. Strandberg, P.Wadhwani, J. Reichert, J. B\u00fcrck , F. Rabanal, A. S. Ullrich (2015) Hydrophobic mismatch demonstrated for membranolytic peptides and their use as molecular rulers to measure bilayer thickness in cells. Sci. Rep. <\/em>5, 9388<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"

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