{"id":17022,"date":"2023-09-14T11:50:48","date_gmt":"2023-09-14T09:50:48","guid":{"rendered":"http:\/\/161.116.26.48\/?page_id=17022"},"modified":"2023-09-21T10:43:38","modified_gmt":"2023-09-21T08:43:38","slug":"novel-adoptive-car-nk-cell-transfer-therapy-in-refractory-invasive-fungal-infection","status":"publish","type":"page","link":"https:\/\/www.fbg.ub.edu\/en\/what-we-do\/technologies-materials-and-licences\/novel-adoptive-car-nk-cell-transfer-therapy-in-refractory-invasive-fungal-infection\/","title":{"rendered":"Novel adoptive CAR-NK cell transfer therapy in refractory invasive fungal infection"},"content":{"rendered":"<h3>Description<\/h3>\n<p>Invasive fungal infections are a cause of high morbidity in immunocompromised patients (e.g., bone marrow transplant recipient, and cancer or ICU admitted patients). Moreover, there is an emergence of fungal infections multi-resistant to available antifungals, which are in turn costly and have significant associated toxicity. All this meaning that mortality in these cases can exceed 70%.<\/p>\n<p>The research group proposes a solution based on Off-the-self allogeneic CD5CAR NK cells for rapid adoptive cell transfer therapy overcoming antifungal drug resistance.<\/p>\n<h3><strong>Current stage of development<\/strong><\/h3>\n<p>The CD5 CAR project is pending of AEMPS\u2019s (Spanish Agency for Medicinal and Sanitary Products) approval for initiation of clinical phase I trial by the end of 2023.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Description Invasive fungal infections are a cause of high morbidity in immunocompromised patients (e.g., bone marrow transplant recipient, and cancer&#8230;<\/p>\n","protected":false},"author":2,"featured_media":17019,"parent":1394,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-tecnologies.php","meta":{"_acf_changed":false,"inline_featured_image":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-17022","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/17022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/comments?post=17022"}],"version-history":[{"count":2,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/17022\/revisions"}],"predecessor-version":[{"id":17148,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/17022\/revisions\/17148"}],"up":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/pages\/1394"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/media\/17019"}],"wp:attachment":[{"href":"https:\/\/www.fbg.ub.edu\/en\/wp-json\/wp\/v2\/media?parent=17022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}